RBP census

RBP-J and ITAM crosstalk

Osteoclasts, multinucleated giant cells derived from the monocyte/macrophage lineage, are the exclusive specialized bone-resorbing cells that are indispensable for skeletal development, bone remodeling and repair and mineral homeostasis. Increased osteoclastogenesis leads to excessive bone resorption in osteoporosis and in inflammatory diseases with bone destruction, such as rheumatoid arthriti...

Vitamin A transport in chicken plasma: isolation and characterization of retinol-binding protein (RBP), prealbumin (PA), and RBP--PA complex.

Vitamin A-transporting protein in chicken plasma was purified by column chromatography on DEAE-Sephadex and Sephadex G-100; the protein formed a complex of retinol-binding protein (RBP) with prealbumin (PA). The molecular weight of the 1:1 molar complex was estimated to be 76,000 by gel filtration, and the sedimentation coefficient (S20,W) was found to be 5.2 S. RBP and PA were dissociated from...

Muscle expression of human retinol-binding protein (RBP). Suppression of the visual defect of RBP knockout mice.

Mice lacking retinol-binding protein (RBP) have low circulating retinol levels. They have severe visual defects due to a low content of retinol or retinyl esters in the eye. A transgenic mouse strain that expresses human RBP under the control of the muscle creatine kinase promoter in the null background was generated. The exogenous protein bound retinol and transthyretin in the circulation and ...

Census of prokaryotic senses.

A millennial myosin census.

The past decade has seen a remarkable explosion in our knowledge of the size and diversity of the myosin superfamily. Since these actin-based motors are candidates to provide the molecular basis for many cellular movements, it is essential that motility researchers be aware of the complete set of myosins in a given organism. The availability of cDNA and/or draft genomic sequences from humans, D...